The budding yeast HRR25 gene product is a casein kinase I isoform.
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Budding and fission yeast casein kinase I isoforms have dual-specificity protein kinase activity.
We have examined the activity and substrate specificity of the Saccharomyces cerevisiae Hrr25p and the Schizosaccharomyces pombe Hhp1, Hhp2, and Cki1 protein kinase isoforms. These four gene products are isotypes of casein kinase I (CKI), and the sequence of these protein kinases predicts that they are protein serine/threonine kinases. However, each of these four protein kinases, when expressed...
متن کاملPrenylated isoforms of yeast casein kinase I, including the novel Yck3p, suppress the gcs1 blockage of cell proliferation from stationary phase.
The GCS1 gene of the budding yeast Saccharomyces cerevisiae mediate the resumption of cell proliferation from the starved, stationary-phase state. Here we identify yeast genes that, in increased dosages, overcome the growth defect of gcs1 delta mutant cells. Among these are YCK1 (CK12) and YCK2 (CKI1), encoding membrane-associated casein kinase I, and YCK3, encoding a novel casein kinase I isof...
متن کاملPalmitoylation and the yeast casein kinase yck2
PALMITOYLATION AND THE YEAST CASEIN KINASE YCK2byIRENE PAPANAYOTOUMay 2011Advisor: Dr. Nicholas G. DavisMajor: PharmacologyDegree: Doctor of Philosophy ! The Saccharomyces cerevisiae type I casein kinase Yck2 is tethered to thecytosolic face of the plasma membrane through palmitoylation of its two C-terminalcysteines. Yck2 palmitoylation is mediated by the Go...
متن کاملA casein kinase I isoform is required for proper cell cycle progression in the fertilized mouse oocyte.
Casein kinase I is a family of serine/threonine protein kinases common to all eukaryotes. In yeast, casein kinase I homologues have been linked to the regulation of growth, DNA repair and cell division. In addition, their subcellular localization to membraneous structures and the nucleus is essential for function. In higher eukaryotes, there exist seven genetically distinct isoforms: (alpha), s...
متن کاملMolecular cloning, expression, and characterization of a 49-kilodalton casein kinase I isoform from rat testis.
We report the molecular cloning and characterization of a 49-kDa form of casein kinase I from rat testis. A cDNA clone encoding the enzyme, designated casein kinase I delta, contained an open reading frame of 1284 nucleotides that predicts a polypeptide of 428 amino acids with a M(r) of 49,121. The predicted amino acid sequence shares 76% identity with casein kinase I alpha, a 37-kDa form recen...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1992
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.89.15.7008